I've listened to Security Now! since the beginning, though I do have quite a backlog to work my way through. Again, it's part of the TWiT network, and it focuses on security, unsurprisingly.
The show is pitched at a fairly basic level, but for me that's just right. I don't have to time to get deep into the subject of security, but Security Now! gives you a good, broad understand of the issues about internet security, and how you can protect yourself. It's very useful, and it often touches upon one of my favourite subjects - cryptography.
Give it a go.